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Fina Biosolutions now offers Recombinant CRM197
EcoCRMTM: “Economical CRM from E. coli

Carrier Proteins

Carrier proteins are used to convert polysaccharides from T-cell independent antigens, into T-cell dependent antigens by linking the two together.  They are also used to improve the immunogenicity of oligosaccharides, peptides and proteins.

CRM197 Carrier Protein

CRM197, a genetically detoxified diphtheria toxin, is widely used as a carrier protein in conjugate vaccines, including effective conjugate vaccines against Streptococcus pneumoniae, Haemophilus influenzae b and Neisseria meningitidis. Fina BioSolutions has developed a highly efficient E. coli expression system for CRM197. We express soluble, properly folded CRM197 in the cytoplasm of E.coli. High expression levels and a simple purification scheme allow us to produce CRM197 at low cost and price it accordingly.

Fina Biosolutions is pleased to offer EcoCRMTM, economical CRM197 from E. coli, to the research and vaccine manufacturing community. Research Grade EcoCRMTM is available now. cGMP EcoCRMTM will be available in early 2020.

EcoCRMTM is shipped on dry ice.

Size Price
1 mg $250
5 mg $750
10 mg $1,250
25 mg $3,525
50 mg $5,500
GMP CRM197 Inquire

BIBLIOGRAPHY: NEW: Bibliography for EcoCRM®, FinaBio’s CRM197, as of May 31, 20211-15 Download Now

POSTER: NEW: Analytical Assessments of CRM197 Download Now

POSTER: NEW: EcoCRM – A Recombinant CRM197 Carrier Protein Download Now

POSTER: EcoCRM: Economical Recombinant CRM197 Download Now

POSTER: Biophysical Evaluation of EcoCRM Download Now

POSTER: EcoCRM: Affordable CRM197 Vaccine Carrier Protein Download Now

JOURNAL ARTICLE: Analytical Comparability Assessments of 5 Recombinant CRM197 Proteins From Different Manufacturers and Expression Systems Download Now

WHITE PAPER: CRM197 is Superior to KLH as a Carrier Protein Download Now

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