Carrier proteins are used to convert polysaccharides from T-cell independent antigens, into T-cell dependent antigens by linking the two together. They are also used to improve the immunogenicity of oligosaccharides, peptides and proteins.
CRM197 Carrier Protein
CRM197, a genetically detoxified diphtheria toxin, is widely used as a carrier protein in conjugate vaccines, including effective conjugate vaccines against Streptococcus pneumoniae, Haemophilus influenzae b and Neisseria meningitidis. Fina BioSolutions has developed a highly efficient E. coli expression system for CRM197. We express soluble, properly folded CRM197 in the cytoplasm of E.coli. High expression levels and a simple purification scheme allow us to produce CRM197 at low cost and price it accordingly.
Fina Biosolutions is pleased to offer EcoCRMTM, economical CRM197 from E. coli, to the research and vaccine manufacturing community. Research Grade EcoCRMTM is available now. cGMP EcoCRMTM will be available in late 2018.
EcoCRMTM is shipped on dry ice.