Fina Biosolutions now offers Recombinant CRM197
EcoCRM®: “Economical CRM from E. coli”
Carrier proteins are used to convert polysaccharides from T-cell independent antigens, into T-cell dependent antigens by linking the two together. They are also used to improve the immunogenicity of oligosaccharides, peptides and proteins.
CRM197 Carrier Protein
CRM197, a genetically detoxified diphtheria toxin, is widely used as a carrier protein in conjugate vaccines, including effective conjugate vaccines against Streptococcus pneumoniae, Haemophilus influenzae b and Neisseria meningitidis. Fina BioSolutions has developed a highly efficient E. coli expression system for CRM197. We express soluble, properly folded CRM197 in the cytoplasm of E.coli. High expression levels and a simple purification scheme allow us to produce CRM197 at low cost and price it accordingly.
Fina Biosolutions is pleased to offer EcoCRM®, economical CRM197 from E. coli, to the research and vaccine manufacturing community. Research Grade EcoCRM® is available now. cGMP EcoCRM® is now available.
BIBLIOGRAPHY: NEW: Bibliography for EcoCRM®, FinaBio’s CRM197, as of May 31, 20211-15
POSTER: NEW: Analytical Assessments of CRM197
POSTER: NEW: EcoCRM – A Recombinant CRM197 Carrier Protein
POSTER: EcoCRM: Economical Recombinant CRM197
POSTER: Biophysical Evaluation of EcoCRM
POSTER: EcoCRM: Affordable CRM197 Vaccine Carrier Protein
JOURNAL ARTICLE: Analytical Comparability Assessments of 5 Recombinant CRM197 Proteins From Different Manufacturers and Expression Systems